What Is Japanese Knotweed — and Is It the Same as Trans-Resveratrol?Updated 2 hours ago
The Resveratrol in the Codeage Centenarian 100 is sourced from Japanese Knotweed Extract — listed on the label as "Resveratrol (from Japanese Knotweed Extract)." Customers familiar with resveratrol supplements may also know the term "Trans-Resveratrol" and wonder whether these refer to the same thing.
What Is Japanese Knotweed?
Japanese Knotweed (Polygonum cuspidatum, also known as Reynoutria japonica) is a fast-growing plant native to East Asia — originally from Japan, China, and Korea. It is one of the most concentrated natural plant sources of resveratrol available and has become the primary botanical source used in dietary supplement manufacturing to produce resveratrol extracts.
Despite its invasive reputation as a garden plant in many Western countries, Japanese Knotweed root has been used in traditional East Asian botanical practice for centuries and is now cultivated commercially for supplement ingredient production.
What Is Trans-Resveratrol?
Resveratrol exists in two primary structural forms — or isomers:
- Trans-Resveratrol — the biologically active form, which is stable and the most commonly used form in dietary supplements
- Cis-Resveratrol — a less stable isomer that is less commonly used in supplementation
When supplement labels or product descriptions reference "Trans-Resveratrol," they are specifying this active isomeric form. Japanese Knotweed Extract is the most common natural source of Trans-Resveratrol in the supplement industry.
You can learn more about resveratrol's chemical forms and research at the National Institutes of Health Office of Dietary Supplements and the National Center for Biotechnology Information (NCBI).
Is the Resveratrol in the Centenarian 100 Trans-Resveratrol?
The Centenarian 100 label lists "Resveratrol (from Japanese Knotweed Extract)" — sourced from Polygonum cuspidatum root, which is the primary natural source of Trans-Resveratrol used in the supplement industry. Each serving provides 200mg of Resveratrol from this source.
Is Japanese Knotweed Safe as a Supplement Ingredient?
Japanese Knotweed root extract standardized for resveratrol content is a widely used and well-established ingredient in the dietary supplement industry. It is used in resveratrol supplements by a broad range of manufacturers globally and has been reviewed by regulatory bodies in multiple markets.
As with any dietary supplement, consult a qualified healthcare professional before use — particularly if you are pregnant, nursing, taking medications, or managing a known medical condition.
Codeage formulas are developed with care and may be subject to adjustments over time. We recommend checking the current product label or page for the most up-to-date ingredient and formulation information.
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