What Is the Difference Between Fisetin and Resveratrol — and Why Does the Centenarian 100 Include Both?Updated 2 hours ago
The Codeage Centenarian 100 includes two individually disclosed polyphenol compounds — 500mg of Fisetin and 200mg of Resveratrol — alongside the 900mg Mediterra Complex. While both are polyphenols studied in the longevity research space, they are chemically distinct compounds from different botanical sources with different structural properties.
What Is Fisetin?
Fisetin is a flavonoid polyphenol sourced in this formula from Rhus succedanea L. It belongs to the flavonol subclass of flavonoids — the same chemical family as quercetin and kaempferol. Fisetin is naturally present in small amounts in strawberries, apples, and certain other plant foods, but is most concentrated for supplement use in Rhus succedanea.
What Is Resveratrol?
Resveratrol is a stilbene polyphenol — a distinct chemical class from flavonoids. It is naturally found in the skin of red grapes, red wine, blueberries, and peanuts. In the Centenarian 100, Resveratrol is sourced from Japanese Knotweed Extract (Polygonum cuspidatum; Root) — one of the most concentrated natural sources of resveratrol available for supplement use.
Resveratrol has been one of the most extensively studied polyphenols in the longevity and cellular health research space for over two decades. You can explore the published research on resveratrol at the National Center for Biotechnology Information (NCBI).
How Are They Different?
| Fisetin | Resveratrol | |
|---|---|---|
| Chemical class | Flavonoid (flavonol) | Stilbene |
| Botanical source in this formula | Rhus succedanea L. | Japanese Knotweed Extract |
| Amount per serving | 500mg | 200mg |
| Natural food sources | Strawberries, apples, onions | Red grape skin, red wine, blueberries |
Why Include Both?
The Centenarian 100 takes a multi-polyphenol approach — combining five distinct plant-derived ingredients in one formula. Fisetin and Resveratrol are each individually dosed and fully disclosed on the label, rather than being hidden within a proprietary blend. Their inclusion together alongside the Mediterra Complex reflects a layered botanical architecture drawing on different polyphenol classes and traditions.
This product is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Codeage formulas are developed with care and may be subject to adjustments over time. We recommend checking the current product label or page for the most up-to-date ingredient and formulation information.
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