What Is the Difference Between Fisetin, Quercetin, and Resveratrol?Updated 2 hours ago
Fisetin, Quercetin, and Resveratrol are three of the most researched plant-derived polyphenols in the cellular longevity and healthy aging space. While they are often mentioned together in supplement discussions, they belong to different chemical subclasses of polyphenols and have distinct botanical sources, molecular structures, and research profiles.
What Are Polyphenols?
Polyphenols are a broad class of naturally occurring plant compounds characterized by multiple phenol rings in their molecular structure. They are found across a wide variety of fruits, vegetables, teas, and botanical extracts and are among the most studied compounds in nutritional science.
Fisetin and Quercetin both belong to the flavonoid family — specifically the flavonol subclass. Resveratrol belongs to a separate chemical family called stilbenes. You can explore the broader polyphenol research landscape at the National Center for Biotechnology Information (NCBI) and the Linus Pauling Institute Micronutrient Information Center.
Fisetin
Chemical class: Flavonoid (flavonol subclass)
Common natural sources: Strawberries, apples, onions, cucumbers, grapes
Fisetin (3,3',4',7-tetrahydroxyflavone) is a flavonol found naturally in small amounts in a variety of fruits and vegetables. It is one of the structurally simpler flavonol compounds and has attracted growing research interest in the cellular longevity space over the past decade.
Fisetin is among the most actively studied polyphenols in academic longevity science. The Mayo Clinic and the Buck Institute for Research on Aging have both been involved in research examining fisetin in the context of cellular aging. You can explore the published fisetin research literature at PubMed.
Quercetin
Chemical class: Flavonoid (flavonol subclass)
Common natural sources: Onions, capers, apples, broccoli, green tea, red wine
Quercetin (3,3',4',5,7-pentahydroxyflavone) is the most widely consumed flavonol in the human diet and one of the most extensively studied polyphenols overall. It is structurally related to fisetin — both are flavonols — but differs in one key position: quercetin has an additional hydroxyl group at the 5-position of its A-ring that fisetin does not. This structural difference gives each compound a distinct profile in the scientific literature.
Quercetin is studied across a broad range of health categories including immune support and cardiovascular wellness. You can explore the quercetin research literature at PubMed.
Resveratrol
Chemical class: Stilbene (distinct from the flavonoid family)
Common natural sources: Red grape skin, red wine, blueberries, peanuts, Japanese Knotweed
Resveratrol is chemically distinct from both fisetin and quercetin. It belongs to the stilbene class of polyphenols — its molecular structure consists of two phenol rings connected by an ethylene bridge, which is fundamentally different from the three-ring flavonoid framework shared by fisetin and quercetin.
Resveratrol has been one of the most studied polyphenols in longevity research for over two decades, with a body of literature focused particularly on its relationship to sirtuins — a family of proteins involved in cellular regulation processes. Japanese Knotweed (Polygonum cuspidatum) is the most concentrated natural botanical source of resveratrol used in supplement manufacturing. You can explore the resveratrol research literature at PubMed.
How These Three Compounds Compare at a Glance?
| Fisetin | Quercetin | Resveratrol | |
|---|---|---|---|
| Chemical class | Flavonoid (flavonol) | Flavonoid (flavonol) | Stilbene |
| Common natural sources | Strawberries, apples, onions | Onions, capers, apples, green tea | Red grape skin, Japanese Knotweed |
| Primary research focus | Cellular longevity | Broad health categories | Cellular longevity, sirtuins |
Are These Compounds Found in Codeage Products?
Codeage offers several formulas that feature one or more of these polyphenols:
- Fisetin and Resveratrol — Centenarian 100 (500mg Fisetin, 200mg Resveratrol)
- Resveratrol — Liposomal NMN Platinum, Liposomal Urolithin A, Brain Focus Vitamins+
- Quercetin — Liposomal Vitamin C+, Liposomal NMN Platinum
This product is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Codeage formulas are developed with care and may be subject to adjustments over time. We recommend checking the current product label or page for the most up-to-date ingredient and formulation information.
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