What Is the Difference Between Urolithin A and Urolithin B?Updated 12 minutes ago

Urolithin A is one of several urolithin compounds that can be produced in the human gut during the digestion of ellagitannins — polyphenols found in pomegranates, walnuts, and certain berries. Urolithins exist as a family of related molecules, and understanding the differences between them helps clarify why Urolithin A specifically has become the most prominent urolithin in the dietary supplement industry.

What Are Urolithins?

Urolithins are a class of naturally occurring compounds produced in the human gut through the metabolic transformation of ellagitannins by gut bacteria. They belong to a broader chemical family called dibenzo-alpha-pyrones and are categorized by their molecular structure — specifically by the number and position of hydroxyl groups on their chemical framework.

The primary urolithins studied in the scientific literature include:

• Urolithin A — the most researched urolithin in the longevity and supplement space
• Urolithin B — a structurally related compound with a distinct hydroxylation pattern
• Urolithin C and D — less commonly studied forms

You can explore the published urolithin research at the National Center for Biotechnology Information (NCBI) and PubMed.

What Is the Structural Difference Between Urolithin A and Urolithin B?

Urolithin A and Urolithin B are structural isomers — they share the same core dibenzo-alpha-pyrone framework but differ in the number and position of their hydroxyl groups:

• Urolithin A contains two hydroxyl groups, positioned at the 3 and 8 positions of the molecule
• Urolithin B contains one hydroxyl group, positioned at the 3 position only

This seemingly small structural difference gives each compound a distinct chemical profile and has contributed to their different research trajectories in the scientific literature.

Why Is Urolithin A More Common in Supplements Than Urolithin B?

Urolithin A has attracted significantly more research attention than Urolithin B and is the most studied urolithin in the context of cellular longevity and mitochondrial biology research. The body of peer-reviewed literature examining Urolithin A is substantially larger than that for Urolithin B, and Urolithin A has been the subject of human clinical studies. As a result of this research focus, Urolithin A has become the dominant urolithin used in dietary supplement formulations, while Urolithin B remains primarily a subject of preclinical research.

Which Urolithin Does the Codeage Liposomal NMN Urolithin A Contain?

The Codeage Liposomal NMN Urolithin A contains Urolithin A — the most researched and most widely used urolithin in the dietary supplement industry — at 500mg per serving, alongside 500mg of NMN (β-Nicotinamide Mononucleotide).

This product is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Codeage formulas are developed with care and may be subject to adjustments over time. We recommend checking the current product label or page for the most up-to-date ingredient and formulation information.

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